Learn more about PMT-BC and
key advances in metabolomics
PMT-BC has previously been published as BESST
Key Publications
Blastocyst and embryo screening selection tool (BESST)
An ultrafast non-invasive embryo selection test for use
immediately prior to embryo transfer,
Early research
Characteristics of populations of granulosa cells from individual follicles in women undergoing ‘coasting’ during controlled ovarian stimulation (COS) for IVF
A.J. Tozer, R.K. Iles, E. Iammarrone, R.A. Nica, C.M.Y. Gillott, Wen XuSong, T. Al-Shawaf, J.G. Grudzinskas
Human Reproduction, Volume 19, Issue 11, 1 November 2004, Pages 2561–2568,
https://doi.org/10.1093/humrep/deh487
The effects of ‘coasting’ on follicular fluid concentrations of vascular endothelial growth factor in women
at risk of developing ovarian hyperstimulation syndrome,
A.J. Tozer, R.K. Iles, E. Iammarrone, C.M.Y. Gillott, T. AlâShawaf, J.G. Grudzinskas, Human Reproduction, Volume 19, Issue 3, March 2004, Pages 522–528,
https://doi.org/10.1093/humrep/deh096
Follicular fluid levels of inhibin A, inhibin B, and activin A levels reflect changes in follicle size but are not
independent markers of the oocyte’s ability to fertilize.
Xuesong Wen, Amanda J. Tozer, Stephen A. Butler, Celia M. Bell, Suzanne M. Docherty, Ray K. Iles,
Fertility and Sterility, Volume 85, Issue 6, 2006, Pages 1723-1729, ISSN 0015-0282,
https://doi.org/10.1016/j.fertnstert.2005.11.058.
Mass spectrometry and Blastocyst evaluation. Current Advancements in Noninvasive Profiling of the Embryo Culture Media Secretome
Raminta Zmuidinaite, Fady I Sharara, Ray K Iles, Int. J. Mol. Sci. 22 (5), 2513 (2021)
https://doi.org/10.3390/ijms22052513
Method of providing a prognosis of successful implantation of a cultured embryo.
Raymond Kruse Iles and Stephen A Butler (2020) European Patent Office EP3198279B1
Bioinformatic identification of euploid and aneuploid embryo secretome signatures in IVF culture media based on MALDI-ToF mass spectrometry,
Ricardo J Pais, Fady Sharara, Raminta Zmuidinaite, Stephen Butler, Sholeh Keshavarz, Ray Iles J Assist Reprod Genet 37, 2189–2198 (2020).
https://doi.org/10.1007/s10815-020-01890-8
Blastocyst and embryo screening selection tool (BESST): an ultrafast non-invasive embryo selection test for use immediately prior to embryo transfer
Raminta Zmuidinaite, Ricardo J Pais, Ray K Iles, Fady I Sharara, Christian Jardine, Stephen A Butler Fertility and Sterility 112 (3), e276 (2019)
https://www.fertstert.org/article/S0015-0282(19)31422-0/fulltext
BESST, a Non-Invasive Computational Tool for Embryo Selection Using Mass Spectral Profiling of Embryo Culture Media
F Sharara, SA Butler, RJ Pais, R Zmuidinaite, S Keshavarz, RK Iles EMJ Repro Health 5: 59-60 (2019)
A non-invasive, rapid method to discriminate euploid and aneuploid embryo by MALDI Tof MS of culture media.
S Keshavarz, F Sharara, R Pais, R Zmuidinaite, R Iles, S Butler, HUMAN REPRODUCTION 34, 254-255
Secretome profile selection of optimal IVF embryos by matrix-assisted laser desorption ionization time-of-flight mass spectrometry
RK Iles, FI Sharara, R Zmuidinaite, G Abdo, S Keshavarz, SA Butler
Journal of assisted reproduction and genetics 36, 1153-1160 (2019)
https://link.springer.com/article/10.1007/s10815-019-01444-7
Optimising Machine Learning Algorithms for the Non-Invasive analysis of the embryo secretome to enhance informed decisions imediately prior to embryo transfer
S Butler, F Sharara, R Zmuidinaite, R Iles, HUMAN REPRODUCTION 33, 126-126 (2018)
Non-invasive selection of optimal embryos immediately prior to embryo transfer using bioinfomatic analysis of spectral data following matrix assisted laser desorbtion/ionisation time of flight mass spectrometry
S.A. Butler, F. Sharara, J. Cooper, J.K. Iles, R. Zmuidinaite G.A. Abdo, S. Keshavarz, R.K. Iles, Fertility and Sterility 108 (3) ,e354 (2017)